Selenoproteins < Proteins (Protein Science) << Compounds of Life @ Wellness Advocate . com

^⌊ SELENOF Gene
^⌊ SELENOK Gene
^⌊ SELENOM Gene
^⌊ SELENOO Gene
^⌊ SELENOS Gene
^⌊ SELENOT Gene
^⌊ SELENOV Gene

Proteins (Protein Science)
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See Also ↔

Selenium (Se) Interrelationships

See Also ↔

Aging & Longevity
Welltrients Guide
Wellness
Fitness (Physical Fitness)
Cleanses & Detoxifying

Selenoproteins

“Selenoproteins”

Selenoprotein
In protein science, a Selenoprotein is any protein that includes a selenocysteine (Se-Cys) amino acid residue.
In our body, the selenium (Se) is a nutritional trace mineral essential for a wide range of roles in metabolism and oxidative stress defense and various health aspects. Selenium (Se) exerts its effects mainly through its incorporation into Selenoprotein as the amino acid, selenocysteine.
Twenty-five selenoprotein genes have been identified in humans and several selenoproteins are broadly classified as antioxidant enzymes.
Examples of selenoproteins include:

Selenoprotein P
Selenoprotein W
Methionine Sulfoxide Reductases
The genes in the selenoproteins gene group include:

DIO1 gene, aka iodothyronine deiodinase 1
DIO2 gene, aka iodothyronine deiodinase 2
DIO2 gene, aka iodothyronine deiodinase 3
MSRB1 Gene (SEPX1 gene), aka methionine sulfoxide reductase B1
GPX1 gene, aka glutathione peroxidase 1
GPX2 gene, aka glutathione peroxidase 2
GPX3 gene, aka glutathione peroxidase 3
GPX4 gene, aka glutathione peroxidase 4
GPX6 gene, aka glutathione peroxidase 6
SELENOF gene, aka selenoprotein F
SELENOH gene, aka selenoprotein H
SELENOI gene, aka selenoprotein I
SELENOK gene, aka selenoprotein K
SELENOM gene, aka selenoprotein M
SELENON Gene (SEPN1 gene), aka selenoprotein N
SELENOO gene, aka selenoprotein O
SELENOP gene (SEPP1 gene), aka selenoprotein P
SELENOS gene, aka selenoprotein S
SELENOT gene, aka selenoprotein T
SELENOV gene, aka selenoprotein V
SELENOW Gene (SEPW1 gene), aka selenoprotein W
SEPHS2 gene, aka selenophosphate synthetase 2
TXNRD1 gene, aka thioredoxin reductase 1
TXNRD2 gene, aka thioredoxin reductase 2
TXNRD3 gene, aka thioredoxin reductase 3
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Selenoproteins

Selenium Deficiencies (Se Deficiencies)

“Selenium Deficiencies (Se Deficiencies)”

Selenium (Se) Deficiency
In our body, the protein and mRNA levels for several Selenoproteins, such as glutathione peroxidase-1 (GPX1 gene), are down-regulated dramatically by a deficiency in selenium (Se) (Selenium Deficiency).

Selenium Deficiencies (Selenium Deficiency diseases)

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References:
Jackson-Rosario SE. et al "Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery" Metallomics. 2010 Feb;2(2):112-6
Reeves MA. et al "The human selenoproteome: recent insights into functions and regulation" Cell Mol Life Sci. 2009 Aug;66(15):2457-78
Kryukov GV. "Characterization of mammalian selenoproteomes" Science. 2003 May 30;300(5624):1439-43
Raines AM. et al "Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents" BMC Genomics. 2011 Jan 12;12:26

†The statements on this Web site have not been evaluated by the Food and Drug Administration (FDA). And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. Nothing presented here is intended as a substitute for prescription medication or any other medical treatment prescribed by your doctor.

Selenoproteins

Selenoprotein

Selenium (Se) Deficiency

Selenium Deficiencies (Selenium Deficiency diseases)

References: