“Plasminogen Activator (PLA)”  

Plasminogen Activator

    In enzyme science, Plasminogen Activator (Pla) is a heterogeneous group of proteolytic enzymes that convert plasminogen to fibrinolysin is a hydrolase enzyme reaction.
    In our body, Plasminogen Activator (Pla) is a blood coagulation factor that plays an important role in the dissolution of blood clots and vascular remodeling.
    Examples of some plasminogen activators include:

• tissue plasminogen activator
• urokinase-Type plasminogen activator
• streptokinases
  • anistreplase
  • streptodornase and streptokinase

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“Complement Factor B”  

    In our body's complement system, Complement Factor B is a glycine-rich, heat-labile serum glycoprotein.

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“Proprotein Convertase 2”  

    In biochemistry, Proprotein Convertase 2 is a subset of serine endopeptidases.

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“Proprotein Convertase 1”  

    In enzyme science, Proprotein Convertase 1 is a subset of serine endopeptidases.

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“Furin”  

    In enzymology, Furin is a hydrolase enzyme reaction.

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“Complement Factor I”  

    In enzymology, Complement Factor I is a hydrolase enzyme reaction.

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“Coagulation Factor XIa (Factor XIa)”  

Factor XIa

    In enzymology, Coagulation Factor XIa (Factor XIa) as a hydrolase enzyme reaction is the activated form of coagulation factor XI is activated to XIa by factor XIIa in the presence of cofactor high-molecular-weight kininogen (HMWK).

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“Proprotein Convertase 5”  

    In enzymology, Proprotein Convertase 5 is a subset of serine endopeptidases.

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“Coagulation Factor VIIa”  

Factor VIIa

    In our body's blood, Coagulation Factor VIIa as a hydrolase enzyme reaction is a serine endopeptidase, the activated form of coagulation factor VII, which activates coagulation factor X in the extrinsic pathway of blood coagulation.

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“Cathepsin G”  

    In enzymology, cathepsin, Cathepsin G is a serine endopeptidase with peptide hydrolase enzyme reaction activity.

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“Acrosin (Acrosomal Proteinase)”  

Acrosin

    In our body, Acrosin (Acrosomal Proteinase), as a hydrolase enzyme reaction, is a trypsin-like enzyme of spermatozoa which is not inhibited by alpha 1 antitrypsin.

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“Thrombin (Thrombase)”  

Thrombin

    In enzyme science, Thrombin as a hydrolase enzyme reaction is a serine endopeptidase enzyme formed from prothrombin that converts fibrinogen to fibrin (factor ia).
    In our body, the blood coagulation factor, Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated G-protein-coupled Rhodopsin-like receptor encoded by members of the F2R receptor gene family (F2R gene family).
   

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“Kallikreins (Kinin-Forming Enzymes)”  

Kallikreins Enzymes (KLK Enzymes)

    In our body, as coagulation factors, Kallikreins are proteolytic enzymes from the prekallikreins in the serine endopeptidase family, important in post-translational processing events, found in normal blood urine and other tissues, and represented by the Kallikrein gene family (KLK gene family).

In our body, the three major forms of Kallikreins are:

• prostate-specific antigen (PSA)
• plasma kallikreins
• tissue kallikreins

Kallikrein Genes (KLK Genes)

    The Kallikrein gene family (KLK gene family) contains the following subsets:

• KLKB1 gene
• KLK1 gene
• KLK2 gene
• KLK32 gene (APS gene, PSA gene)
• KLK4 gene
• KLK5 gene (SCTE gene)
• KLK6 gene
• KLK7 gene (SCCE gene)
• KLK8 gene
• KLK9 gene
• KLK10 gene
• KLK11 gene (TLSP gene)
• KLK12 gene
• KLK13 gene (KLK-L4 gene)
• KLK14 gene
• KLK15 gene
• KLKP1 gene formerly called kallikrein 31 pseudogene (KLK31P gene)

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“Mannose-Binding Protein-Associated Serine Proteases”  

Mannan-Binding Lectin Serine Proteases

    In our body's complement system, the a href="?dgl=60673">Mannose-Binding Protein-Associated Serine Proteases (Mannan-Binding Lectin Serine Proteases) are serum serine proteases (serine endopeptidases), which participate in complement activation, activated when complexed with the mannose-binding lectin.
    In our body, the Mannose-Binding Protein-Associated Serine Proteases cleave complement C4 and complement c4 to form c4b2a, the classical pathway C3 convertase.
    Examples of mannan-binding lectin serine proteases include:

• mannan-binding lectin-associated serine protease 1
• mannan-binding lectin-associated serine protease-2

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“Coagulation Factor XIIa (Factor XIIa)”  

Factor XIIa

    In biochemistry, Coagulation Factor XIIa (Factor XIIa) as a hydrolase enzyme reaction is the activated form of coagulation factor XII.

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“Fibrinolysin (Protease F)”  

Plasmin (Fibrinolysin)

    In our body, Fibrinolysin is a product of the lysis of plasminogen (profibrinolysin) by plasminogen activators, composed of two polypeptide chains.
    In our body, Fibrinolysin, as a serine endopeptidase process, is a major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.

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“Chymotrypsin”  

    In enzymology, Chymotrypsin, a serine endopeptidase digestive enzyme, is a hydrolase enzyme reaction, that selectively cleaves aromatic amino acids on the carboxyl side.
    In our body's pancreas, Chymotrypsin is secreted by the pancreas as its zymogen, synthesized in the pancreas via protein biosynthesis from the enzymatically inactive precursor chymotrypsinogen carried in the pancreatic juice to the duodenum where it becomes activated by trypsin.

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“Trypsin”  

    In our body's digestive system, Trypsin is a serine endopeptidase, formed from the inactive proenzyme trypsinogen in the pancreas, converted into its active form by enteropeptidases (enterokinases) in the duodenum.
    In enzymology, Trypsin ss a hydrolase enzyme reaction catalyzes hydrolysis of the carboxyl group of either arginine or lysine.

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